Effect of Tanreqing Injection on Serum Levels of TGF-β and MMP-9 of Patients with COPD
10.13241/j.cnki.pmb.2017.22.030
- VernacularTitle:痰热清注射液对COPD患者血清TGF-β与MMP-9水平的影响
- Author:
Yujuan WANG
;
Yani XUE
;
Wei CHEN
;
Jianquan GAO
;
Wenlin LIU
- Keywords:
Chronic pulmonary obstruction pulmonary disease;
Tanreqing injection;
Transforming growth factor-β;
Matrix metalloproteinases-9
- From:
Progress in Modern Biomedicine
2017;17(22):4325-4329
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effect of tanreqing injection on the serum levels of transforming growth factor-β (TGF-β) and matrix metalloproteinases-9 (MMP-9) of patients with chronic obstructive pulmonary disease (COPD).Methods:102 patients with COPD were divided into the control group and the observation group according to random number table method,52 cases in each group.The control group was treated with routine therapy,and the observation group was treated with Tanreqing injection based on the control group.The serum TGF-β,MMP-9 levels,forced vital capacity (FVC),1 s forced expiratory volume (FEV1),partial pressure of carbon dioxide (PaCO2),oxygen partial pressure (PaO2),CD4+,CD86,CD4+/CD8+,syndrome integral,clinical efficacy and incidence of side effects were observed and compared between the two groups.Results:After treatment,the serum TGF-β,MMP-9 levels,PaCO2 and syndrome integral of observation group were significantly lower than those of the control group,the PaO2,CD4+,FVC,FEV1,CD4+/CD8+ and the clinical efficacy of observation group were obviously higher than those of the control group (P＜0.05).There was no significant difference in the incidence of side effects between the two groups (P＞0.05).Conclusion:Tanreqing injection could effectively reduce the serum levels of TGF-β and MMP-9,and improve the arterial blood gas,lung function and immune function in treatment of patients with COPD.
