High Expression of Long Non-coding RNA HOTTIP Indicates Poor Prognosis in Cancers: Evidence from Six Studies
10.13241/j.cnki.pmb.2017.22.043
- VernacularTitle:肿瘤中高表达的长链非编码RNA HOTTIP提示较差预后:六项研究的结果汇总
- Author:
Ying CHEN
;
Guoqing WEI
;
Hongwei XIA
;
Feng BI
;
Ming LIU
- Keywords:
Meta-analysis;
Long non-coding RNA;
HOTTIP;
Cancer;
Prognosis
- From:
Progress in Modern Biomedicine
2017;17(22):4376-4381
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The significant role of long non-coding RNAs (lncRNAs) in early diagnosis and predicting prognosis has been recognized in various cancers recently.However,the prognostic value of HOXA transcript at the distal tip (HOTTIP),a vital lncRNA in tumorigenesis,remains unclear.In this study,we evaluated its prognostic value by analyzing the correlation of HOTTIP expression with overall survival (OS),lymph node metastasis (LNM) and distant metastasis (DM) in different cancer types by meta-analysis.Methods:We performed a systematic search in PUBMED,MEDLINE,Web of Science and Cochrane Library update to November of 2016.A total of 604 patients from 6 studies were included in final analysis and went through a quantitative meta-analysis by Review manager 5.3.Results:We demonstrated that high expression of HOTTIP had a significant correlation with poor OS (hazard ratio [HR] =2.37,95％ confidence interval [CI] =1.81-3.10,p＜0.001),high LNM rate (odds ratio [OR]=2.29,95％CI=1.54-3.40,p＜0.001) as well as more DM occurrence (OR=3.30,95％CI=1.78-6.12,p＜0.001).Conclusion:Our results indicated that long non-coding RNA HOTTIP may serve as a potential prognostic biomarker in cancer progression.
