Research Progress of SERPINE Family in Fibrosis Disease
10.13241/j.cnki.pmb.2017.22.046
- VernacularTitle:SERPINE家族在纤维化疾病中作用的研究进展
- Author:
Tianshi LI
;
Zhenfeng GUO
;
Muge QILI
;
Dandan ZHAO
;
Xuelian LI
- Keywords:
SERPINE;
Plasminogen activator inhibitor (PAI-1);
Serine protease inhibitors (PN-1);
Fibrosis
- From:
Progress in Modern Biomedicine
2017;17(22):4391-4393,4267
- CountryChina
- Language:Chinese
-
Abstract:
Serine protease inhibitor (serpin) is a kind of serine protease activity regulator,which including nine subfamilies (SERPIN A ～ I).SERPINE (Serpin Peptidase Inhibitor,Clade E) can regulate many important life processes.In this paper,the physical and chemical properties,mechanisms and regulatory factors of SERPINE1 and SERPINE2 in the two important members of SERPINE family are introduced,and the research progress of SERPINE family in the fibrosis related diseases is described.
