Expression and Clinical Significance of c-Src in the Epithelial Ovarian Carcinoma
10.13241/j.cnki.pmb.2017.26.005
- VernacularTitle:c-Src在上皮性卵巢癌组织中的表达及意义
- Author:
Lina GU
;
Genying LI
;
Linan XING
;
Yue FENG
;
Yunyan ZHANG
- Keywords:
Cell sarcoma;
Epithelial ovarian carcinoma;
Prognosis;
Clinical significance
- From:
Progress in Modern Biomedicine
2017;17(26):5022-5028
- CountryChina
- Language:Chinese
-
Abstract:
Objective:we aim to determine the relationship between Cell sarcoma (c-Src) expression in patients with EOC and the disease phenotype.Methods:c-Src expression was evaluated using Western blotting analysis in 21 ovarian carcinomas and 4 normal ovarian tissues.Immunohistochemistry was used to evaluate c-Src expression in 134 ovarian carcinomas and 26 normal ovarian tissues.The association between c-Src expression and clinically pathologic characteristics were also assessed in these patients.Results:Our results indicated elevated c-Src protein in EOCs compared with that in normal tissues.The overexpression of c-Src was significantly associated with aggressive features,such as advanced disease stage,poor histological grade,lymph node metastasis,and tumor recurrence (P＜0.05).In addition,the overexpression ofc-Src is significantly associated with EOCs' prognosis.Conclusion:c-Src overexpression was significantly associated with the malignant biological behavior of tumor,suggesting c-Src as a potential preventive target in these patients.
