Preliminary study about effect of prolactin and lymphocyte subsets on immune related indexes in patients with schizophrenia

VernacularTitle:泌乳素与淋巴细胞亚群对精神分裂症患者免疫相关指标影响的初步研究
Author: Dan LI ; Lili ZHU ; Qiong GAO ; Jie XU ; Ping LIN
Keywords: schizophrenia; prolactin; lymphocyte subsets; immunoglobulin
From: International Journal of Laboratory Medicine 2017;38(6):723-724,728
CountryChina
Language:Chinese
Abstract: Objective To preliminarily study the effect of high concentration prolactin (PRL) on the immune system in schizo-phrenic patients by analyzing the changes of lymphocyte subsets and immunoglobulins (IgG ,IgM ,IgA) levels .Methods The flow cytometry was used to detect the T lymphocytes CD3+ ,CD4+ and CD8+ subsets ,NK cell percentages and CD4+ /CD8+ ratio re-spectively .The three humoral immune indicators(IgG ,IgM ,IgA) in peripheral blood were detected by using the immunoturbidimet-ric turbidimetric method .The data were analyzed by adopting the analysis of variance .Results Compared with the healthy control group and schizophrenia normal PRL group ,T lymphocytes CD4+ subsets percentages and CD4+ /CD8+ ratio as well as IgG were increased in the schizophrenia PRL increase group(P<0 .05) ,while the percentage of NK cells was decreased(P<0 .05) .Conclu-sion High concentration PRL may have a certain effect on the immune system by influencing the balance among lymphocyte sub-sets and the production of immunoglobulins .