Longitudinal DTI study of the corpus callosum in patients with diffuse axonal injury

VernacularTitle:弥漫性轴索损伤患者胼胝体DTI纵向评估
Author: Dacong ZHAO ; Guanghua LU ; Jiang GUO ; Xiaoyu SUN ; Fang LI ; Hui YU
Keywords: diffuse axonal injury; corpus callosum; diffusion tensor imaging
From: Journal of Practical Radiology 2017;33(4):503-506,529
CountryChina
Language:Chinese
Abstract: Objective To investigate microstructure of the corpus callosum(CC) in subacute diffuse axonal injury(DAI) patients and its the longitudinal change in a short time.Methods 21 patients with subacute DAI were enrolled successively in this study,and in which 12 patients were reexamined followed-up with DTI a month later (31.5 d±6.2 d,28-43 d),and then 12 gender and age matched healthy controls were recruited.The DTI data of all subjects were acquired on at a 3.0T MRI.The CC was divided into six segments:the genu, rostral mid-body, anterior mid-body,posterior mid-body, isthmus, and splenium.ROIs were placed on each segment on color fractional anisotropy (FA) maps in the midsagittal plane manually.The FA and apparent diffusion coefficient(ADC) values of each subregion of CC were measured and compared between subacute DAI group,follow-up group and controls respectively.In addition,a related analysis between DTI parameters of each sub-region of CC and GCS on admission was done by using person correlation analysis.