Oxaliplatin, 5-fluorouracil and Leucovorin (FOLFOX-4) Combination Chemotherapy as a Salvage Treatment in Advanced Gastric Cancer.
- Author:
Young Saing KIM
1
;
Junshik HONG
;
Sun Jin SYM
;
Se Hoon PARK
;
Jinny PARK
;
Eun Kyung CHO
;
Jae Hoon LEE
;
Dong Bok SHIN
Author Information
1. Division of Hematology/Oncology, Department of Internal Medicine, Gachon University Gil Hospital, Incheon, Korea. dbs@gilhospital.com
- Publication Type:Original Article
- Keywords:
FOLFOX-4;
Salvage treatment;
Stomach neoplasms
- MeSH:
Anorexia;
Disease-Free Survival;
Drug Therapy, Combination;
Fluorouracil;
Humans;
Leucovorin;
Neutropenia;
Organoplatinum Compounds;
Stomach Neoplasms
- From:Cancer Research and Treatment
2010;42(1):24-29
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study was designed to determine the efficacy and safety of FOLFOX-4 chemotherapy as a salvage treatment for patients with advanced gastric cancer (AGC). MATERIALS AND METHODS: The AGC patients with an ECOG performance status of 0~1 and progressive disease after prior treatments were registered onto this phase II trial. The patients received oxaliplatin (85 mg/m2 on day 1), leucovorin (200 mg/m2 on days 1 and 2) and 5-fluorouracil (400 mg/m2 as a bolus and 600 mg/m2 as a 22-hour infusion on days 1 and 2) every 2 weeks. RESULTS: For the 42 treated patients, a total of 228 chemotherapy cycles (median: 5, range: 1~12) were administered. Twenty-nine patients (69%) received FOLFOX-4 chemotherapy as a third-(50%) or fourth-line (19%) treatment. On the intent-to-treat analysis, 9 patients (21%) achieved a partial response, which was maintained for 4.6 months. The median progression-free survival and overall survival were 3.0 months and 6.2 months, respectively. The frequently encountered toxicities were neutropenia and gastrointestinal side effects, including anorexia. Although there was one possible treatment-related death, the toxicity profiles were generally predictable and manageable. CONCLUSION: Salvage chemotherapy with FOLFOX-4 is an effective and tolerable regimen for those heavily pretreated AGC patients who have a good performance status.
