Safety and effectiveness of ozone versus hyaluronic acid for treating knee osteoarthritis:a Meta analysis
10.3969/j.issn.1671-8348.2017.09.028
- VernacularTitle:臭氧与透明质酸治疗膝骨性关节炎安全性和有效性的Meta分析
- Author:
Bingyan HU
;
Jinwei AI
;
Chufan LIU
;
Qiong CHENG
;
Zhongjun YAO
- Keywords:
osteoarthritis,knee;
ozone;
hyaluronic acid;
Meta-analysis
- From:
Chongqing Medicine
2017;46(9):1240-1245,1248
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the safety and effectiveness between ozone (O3) and hyaluronic acid (HA) in treating knee osteoarthritis(KOA) by using the meta analysis method.Methods The relevant randomized controlled trials(RCTs) in PubMed,Cochrane Library (issue 1,2016),Embase,CNKI,CBM,VIP,and Wan-Fang databases were retrieved from their establishment to January 23,2016.Two reviewers independently screened the literatures,extracted the data and evaluated the quality of the included RCTs.The results were performed the statistical analysis by using the RevMan5.3 and Stata13.0 software.Results Twenty RCTs involving 2 136 KOA patients were included.Compared with the HA treatment of KOA,the O3 treatment had higher treatment effective rate[odds ratio(OR) =2.78,P＜0.01],and better pain relief effect[at 1,3,6 month after treatment:mean difference(MD) =-0.25,-0.71,-1.70,P＜0.01].There were no statistically significant differences in complications between the two treatment methods[OR=0.84,P=0.56].Conclusion Current evidences indicate that the short-term therapeutic effect of O3 for KOA is superior to HA,and the safety is similar.
