The role of cystine/glutamate antiporter on the pathogenesis of glioma and the relative applications of anesthetics
10.3760/cma.j.issn.1008-1372.2017.02.047
- VernacularTitle:胱氨酸/谷氨酸逆转运体对胶质瘤的作用及麻醉相关应用前景
- Author:
Xinyue WANG
;
Haiyun WANG
- Keywords:
Vesicular glutamate transport proteins;
Cystine;
Glioma;
Anesthesia;
Review
- From:
Journal of Chinese Physician
2017;19(2):319-320,封3
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of glioma has been increasing in recent years,and threatened the human health seriously.Cystine/glutamate antiporter (system xc-) is one of the important glutamate transporters in the central nervous system,both the expression of system xc and the extracellular glutamate concentration increase in the course of brain tumor's development.Hence system xc-plays an essential role in the process of brain tumor genesis,it has become an important research field in brain tumor in the past decades.Our present review expound the important role of system xc-in the process of glioma genesis and development as well as provide theoretical foundation and new strategies for the clinical treatment and the application of drugs by connecting with anaesthetics and the effects of system xc on glioma.
