Inhibition of glutamine on inflammation of rats with pneumonia induced by Klebsiella pneumonia
10.3969/j.issn.1671-8348.2016.33.005
- VernacularTitle:谷氨酰胺对克雷伯杆菌引起的大鼠肺炎炎症的抑制作用
- Author:
Gang YU
;
Liping JIAN
- Keywords:
glutamine;
Klebsiella pneumonia;
pneumoniae;
inflammation;
NF-κB signal pathway
- From:
Chongqing Medicine
2016;45(33):4622-4624,4628
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the inhibition effect of glutamine on the inflammation of rats with pneumonia induced by Klebsiella pneumoniae.Methods Thirty-six SD rats were randomly divided into the normal group,model group and glutamine treatment group.The rat pneumonia model was established by intratracheal instillation of Klebsiella Bacillus pneumonia.Results Compared with the model group,the glutamine treatmernt group could reduce the ratio of W/D(5.98±0.29)vs.(4.32±0.33)(P＜ 0.05),alleviated the lung tissue edema,inflammatory cell infiltration and then improved the morphology of the lung tissue,inhibited the IL-6,IL-1 and TNF-α secretion in serum and lung homogenate(P＜0.05),and inhibited the level of NF-κB p65 and IκBα phosphorylation.Conclusion Glutamine inhibits the inflammation of rats with pneumonia induced by Klebsiella pneumoniae,which might be related to NF-κB signal pathway.
