Analysis on minimum alveolar effective concentration of sevoflurane for laryngeal mask airway insertion under general anesthesia in premature infants
10.3969/j.issn.1671-8348.2016.33.023
- VernacularTitle:早产儿全身麻醉置入喉罩时七氟烷的最低肺泡有效浓度分析
- Author:
Qiang WANG
;
Chao GAO
;
Lan YAO
;
Lan GAO
;
Yi FENG
- Keywords:
premature infants;
laryngeal mask airway;
sevoflurane;
MAC
- From:
Chongqing Medicine
2016;45(33):4678-4679,4683
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the minimum alveolar concentration(MAC) of sevoflurane without body movement during laryngeal mask airway(LMA)intubation in premature infants less than 37 weeks of corrected gestational age undergoing total inhalation general anesthesia induction.Methods Twenty-one ASA Ⅰ or Ⅱ premature infants less than 37 weeks of corrected gestational age undergoing elective inhalation general anesthesia were enrolled in this study.At first,the general anesthesia induction was started by inhaling 6 ％ sevoflurane.After the premature infant lost consciousness,the end tidal sevoflurane concentration(ET-sev)was adjusted to the predetermined concentration and maintained stable for 15 min.After that,LMA was inserted.The up-anddown sequential allocation was used to determine MAC.The initial ETsev was 2 ％,which was increased or decreased by 1 gradient concentration in the next case according to the LMA insertion body movement response.The adjacent concentration gradient was 0.2％.The midpoint from th body movement response to non-body movement response was set as the balance point and the mean value of the concentrations of sevoflurane at all the balance points were calculated as MAC.Results The end tidal sevoflurane con centration without the body movement responses to LMA insertion was 1.71％.Conclusion The MAC of sevoflurane without the body movement responses to LMA insertion in premature infants less than 37 weeks of corrected gestational age is 1.71％,which is lower than that in the normal children and probably because imperfect central nervous system development in premature infants.
