A study on impairment of renal function in hydronephrosis monitored byintravoxel incoherent motion MR imaging
10.3969/j.issn.1002-1671.2017.04.032
- VernacularTitle:IVIM-MRI监测白兔肾积水肾功能损害的研究
- Author:
Renli CEN
;
Jiaoxiang CHEN
;
Qiao ZOU
;
Yongsheng YE
;
Xiaomei WU
;
Xinchun LI
;
Wenhao ZHANG
;
Qiuhua MENG
- Keywords:
magnetic resonance imaging;
intravoxel incoherent motion;
hydronephrosis;
renal function
- From:
Journal of Practical Radiology
2017;33(4):611-614,621
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of intravoxel incoherent motion MR imaging (IVIM-MRI)on monitoring impairment of renal function in hydronephrosis.Methods Left hydronephrosis model of Healthy New-Zealand rabbits made by ureteral incomplete obstruction were scanned by IVIM-MRI at 4, 8, 12, and 16 weeks.The change of IVIM-MRI quantitative parameters (ADC values, D values, D* values, and f values) in left hydronephrosis kidney were observed.The correlation between these parameters and glomerular filtration rate (GFR) were evaluated.Results ADC values, D values, D* values and f values at cortex and medulla in left hydronephrosis model of rabbits decreased gradually in the progression of renal damage after 4, 8, 12, and 16 weeks.For D value, f value and ADC values, there was statistical significant difference among the group of 12 weeks, the group of 16 weeks, the control group, and the group of 4 weeks;statistical significant difference was also observed between the group of 8 weeks and the group of 16 weeks by LSD contrast.ADC values, D values, D* values, and f values were positively correlated to GFR at 4, 8, 12, and 16 weeks for left hydronephrosis model of rabbits.Conclusion IVIM-MRI could monitor impairment of renal function in hydronephrosis dynamically.
