Expression of HK2 in prostate cancer and its effect on malignant phenotype of prostate cancer cells
10.13315/j.cnki.cjcep.2017.02.007
- VernacularTitle:HK2基因在前列腺癌中的表达及其对前列腺癌细胞恶性表型的影响
- Author:
Tao TAO
;
Zhou SHEN
;
Ping XIANG
;
Tao HUANG
;
Shuqiu CHEN
;
Qiang XUAN
;
Jun XIAO
- Keywords:
prostate neoplasms;
HK2;
glucose metabolism;
proliferation;
apoptosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(2):149-152,157
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression of HK2 in human prostate cancer (PCa) tissues and its effect on malignant phenotype of prostate cancer cells.Methods HK2 expression in PCa tissues was determined by microarray database and immunohistochemical staining.Subsequently,the change of cellular phenotype was detected by glycometabolism kit,CCK-8 kit,and flow cytometry after HK2 knockdown.Results HK2 expression was elevated followed by prostate cancer development.HK2 depletion inhibited cellular proliferation and aerobic glycolysis,and increased the ratio of early apoptosis.Conclusion HK2 expression increases in the process of PCa malignant progression.It plays a critical role in cellular proliferation,glycometabolism,and apoptosis,the mechanism of which needs further exploration.
