Study on Association with Expression in Patients with Chronic Kidney Disease
10.3969/j.issn.1671-7414.2017.02.020
- VernacularTitle:血清人附睾蛋白4表达与慢性肾脏病的相关性研究
- Author:
Meihong LU
;
Chunlan YANG
;
Rongrong JING
;
Chunjing JIN
;
Hui CONG
- Keywords:
chronic kidney disease;
human epididymal protein 4;
renal function
- From:
Journal of Modern Laboratory Medicine
2017;32(2):75-77,81
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of human epididymal protein 4 (HE4) in chronic kidney disease (CKD) and its clinical value.Methods From April 2014 to December 2015,Serum samples of 92 non-cancer patients diagnosed as CKD and 84 healthy controls were collected in Nantong University Hospital.HE4,BUN,Scr,Cys C and β2MG were detected.The difference of HE4 expression in different stages of CKD and the correlation of HE4 with Urea,Scr,Cys C and β2MG were analysized,respectively.ROC curve was used to evaluate the auxiliary diagnostic value of HE4,BUN,Scr,Cys C and β2MG.Results The serum HE4 expression in patients with impaired renal function was 388.2 (130.1～1 659.5)mIu/ L,(F=16.237,P=0.001).Which was significantly higher than that in the control group [38.1 (32.77 ～ 48.17)mIu/L].The serum HE4 expression was increased by the stage of renal damage and the difference was existed among different groups (P＜0.05).HE4 expression was positive related with Cys C and β2MG.The AUC of HE4,BUN,Scr,Cys C and β2MG were 0.878,0.785,0.816,0.874 and 0.819,respectively.Conlusion It needs to consider the exsits of impaired renal function when the HE4 was detected.The HE4 might be a novel early diagnostic indication for CKD.
