Clinical Significance of Autoantibodies and Thyroid Function in Patients with Recurrent Spontaneous Abortion
10.3969/j.issn.1671-7414.2017.02.027
- VernacularTitle:复发性自然流产患者自身抗体和甲状腺功能的检测及临床意义
- Author:
Jing DU
;
Baozhu ZHENG
;
Yong XIA
;
Yaoming YAN
;
Hui TANG
;
Wei ZHOU
;
Hong LU
;
Chao YANG
- Keywords:
recurrent spontaneous abortion;
antinuclear antibodies;
antithyroid antibodies;
thyroid function
- From:
Journal of Modern Laboratory Medicine
2017;32(2):98-101,105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance of antinuclear antibody (ANA),anti-thyroid peroxidase antibody (TPO-Ab) and antithyroglobulin antibody (Tg-Ab),thyroid stimulating hormone (TSH),free triiodothyronine (FT3),free thyroxine (FT4) in patients with recurrent spontaneous abortion (RSA).Methods 46 women with RSA diagnosis in out patient department in Peking University Shenzhen Hospital from March 2015 to December 2016 were recruited as the study group,20 women with normal childbirth history were enrolled as the control group,ANA was detected by indirect immunofluorescence (IIF) assay and ELISA,TSH,FT3 and FT4 were detected by chemiluminescence immunoassay technology.Results The positive rates of ANA(IIF),TPO-Ab and Tg-Ab in patients with RSA were 24％,24％ and 15％ respectively which were significantly higher than those in healthy control (P＜0.05).Serum levels of TSH,TPO-Ab and Tg-Ab in patients with RSA were 2.70 ± 1.38 mIU/L,38.99 ± 10.18 IU/ml and 3.07 ± 1.69 IU/ml respectively,which were significantly higher than those in healthy cases (P＜0.05).Conclusion ANA and antithyroid antibodies were closely related with RSA.It is very important to screen ANA and antithyroid antibodies for etiological diagnosis and appropriate intervention in patients with RSA to reduce the incidence of abortion.
