Clinical study of Xuebijing Injection in treatment of capillary leak syndrome
10.3969/j.issn.1673-4130.2017.07.019
- VernacularTitle:血必净注射液在毛细血管渗漏综合征治疗中的临床研究
- Author:
Liyan ZHANG
;
Lipeng ZHANG
;
Xuefang WANG
;
Xiuming LIU
;
Meng MEN
- Keywords:
xuebijing;
capillary leak syndrome;
vascular endothelial growth factor
- From:
International Journal of Laboratory Medicine
2017;38(7):919-920,923
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical application effect of Xuebijing Injection in the treatment of capillary leak syndrome.Methods One hundred patients with capillary leak syndrome in our hospital from January 2013 to April 2016 were selected and randomly divided into the control group and observation group according to the ID number of admission.The two groups were given the Western medicine routine therapy of capillary leak syndrome.The observation group was simultaneously given Xuebijing Injection.The APACHE II score,Mashall score and hemodynamics were compared between the two groups.The disease condition change was dynamically observed.Results The APACHE II score and Mashall score before and after treatment in the observation group were significantly suprior to those in the control group(P<0.05);the peripheral blood circulating endothelial cells (CEC) number at admission in the two groups were higher than the normal level,the CEC content after taking the treatment was gradually decreased (P<0.05),but the CEC content decrease in the observation group was less than that of the control group (P<0.01);were observed before and after the treatment group APACHE II and Mashall score was significantly better than the control group (P<0.05);but the CEC content in the observation group was significnatly superior to the control group(P<0.01);the expressions of vascular endothelial growth factor (VEGF),TNF alpha and interleukin-6 (IL-6) in the observation group were better than those in the control group (P<0.05).Conclusion Using Xuebijing Injection in treating capillary leak syndrome can effectively protect the vascular endothelial cells,improves the living quality of patients and can be popularized and applied in clinical treatment.
