Relationship between insulin resistance with cardiac function and cardiovascular events in patients with obstructive sleep apnea syndrome
10.3969/j.issn.1673-4130.2017.07.027
- VernacularTitle:OSAS患者胰岛素抵抗与患者心功能及心血管事件的关系
- Author:
Caifeng ZHENG
;
Wenxu ZHANG
- Keywords:
insulin resistance;
obstructive sleep apnea syndrome;
cardiac function
- From:
International Journal of Laboratory Medicine
2017;38(7):941-942,945
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between insulin resistance with cardiac function and cardiovascular events in the patients with obstructive sleep apnea syndrome(OSAS).Methods Eithy-eight cases of SHAS in our hospital from August 2015 to August 2016 were selected as the research subjects,and contemporaneous 20 persons undergoing healthy physical examination served as the control group.The blood glucose metabolism indicators were detected for evaluiating the level of insulin resistance.The insulin resistance and glucose metabolism indexes were compared between the two groups.The relatioship between insulin resistance with cardiac function and cardiovascular events in the OSAS was investigated.Results BMI,HOMA-IR,FPG and FINS in the observation group were (28.1± 3.9),(4.7 ±1.9),(4.8± 0.9) and (19.8± 3.7) respectively,which were significantly higher than those in the healthy control group,LVEF in the observation group was (58.7±5.6)%,which was significantly lower than that in the control group,LVEDP,RVEDP and mPAP in the observation group were 8.6±1.8,5.4±0.9 and 25.4±1.9 respectively,which were significantly higher than those in the control group,the multivariate analysis results indicated that LVEF<55%(P=0.014) and HOMA-IR>4.5(P=0.04) were the independent risk factors for cardiovascular events in OSAS patients.Conclusion The insulin resistance has obvious correlation with the cardiac function in OSAS patients.
