Preliminary study on value of lymphocyte function detection in diagnosis and therapy of Henoch-Schonlein purpura
10.3969/j.issn.1673-4130.2017.07.008
- VernacularTitle:淋巴细胞功能测定对小儿过敏性紫癜诊断与治疗的价值初探
- Author:
Lijuan BAO
;
Wenli LI
;
Lei PI
;
Baidu ZHANG
- Keywords:
henoch-schonlein purpura;
flow cytometry;
lymphocyte subsets
- From:
International Journal of Laboratory Medicine
2017;38(7):890-891,894
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of peripheral blood lymphocyte function in the children patients with acute phase of Henoch-Schonlein purpura(HSP),and to explore its significance in the diagnosis and therapy of HSP.Methods The peripheral blood lymphocytes subsets CD3+,CD4+,CD8+,CD4+/CD8+,CD19+ and NK cells(CD16++ CD56+) were detected in 51 children patients with acute phase of HSP and 40 children undergoing physical examination by flow cytometry(FCM Results Compared with the control group,the counts of peripheral blood CD4+,CD4+/ CD8+and NK cells CD16++ CD56+) in the acute stage of the HSP group were significantly decreased(P<0.01),while the proportions of CD8+ and CD19+cells were significantly increased(P<0.05,P<0.01).Conclusion The immunity dysfunction exists in the children patients with acute phase of HSP.The peripheral blood lymphocyte function detection has an important significance for the early diagnosis and treatment of HSP.
