The origin, marker, regulation and therapeutic potential of hepatic oval cells
10.3969/j.issn.1672-8467.2017.02.015
- VernacularTitle:肝卵圆细胞的起源、标志物、调控和应用前景
- Author:
Zhengyang WANG
- Keywords:
hepatic oval cell;
liver injury;
marker;
signaling pathways
- From:
Fudan University Journal of Medical Sciences
2017;44(2):213-216,230
- CountryChina
- Language:Chinese
-
Abstract:
The liver plays an vital role in glucose and lipid metabolism,synthesis of plasma proteins,and detoxification of xenobiotics.Liver chronic disease is one of the leading causes of death in China.Liver mass can be restored by two mechanisms:division of hepatocytes and hepatic oval cells (HOCs) proliferation and differentiation.However,the origin,specific markers and signaling pathways of HOCs have not been fully elucidated.Recent researches in HOCs isolation methods and genetic lineage tracing have enabled investigators to study multiple aspects of HOCs origin and biology.We reviewed the previous researches in detail.
