Homology analysis of clinically isolated and colonized linezolid-resistant Enterococcus faecalis strains from a patient
10.3969/j.issn.1671-9638.2017.04.013
- VernacularTitle:利奈唑胺耐药粪肠球菌感染患者临床分离株与定植株同源性分析
- Author:
Zhangya PU
;
Zhijian YU
;
Zhong CHEN
;
Xiangbin DENG
;
Bing BAI
;
Duoyun LI
;
Xiaojun LIU
;
Xueying HAN
;
Fojun LIN
;
Qiwen DENG
- Keywords:
linezolid;
Enterococcus faecalis;
clinical resistance;
colonization;
homology
- From:
Chinese Journal of Infection Control
2017;16(4):343-345,350
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the homology characteristics of clinicaly isolated and colonized linezolid(LZD)-resistant Enterococcus faecalis (E.faecalis) strains from a patient.Methods Ten E.faecalis strains (2 were isolated from urine specimens and 8 were from stool specimens) isolated from a patient with pulmonary infection were performed antimicrobial susceptibility testing, homology of E.faecalis was determined by pulsed-field gel electrophoresis (PFGE).Results Before and after patients received LZD therapy, 2 E.faecalis strains isolated form urine specimens were both resistant to LZD (MICs: 8 mg/mL, 16 mg/mL, respectively), among 8 strains from stool specimens (6 were isolated before therapy, and 2 were isolated after therapy), LZD susceptible, intermediate, and resistant strains were 4, 2, and 2 respectively(MICs: 0.25-12 mg/mL).10 strains of E.faecalis were homologous by PFGE typing.Conclusion In this case, the detection of E.faecalis from urinary tract and intestinal tract is homologous, which suggested that LZD-resistant Enterococcus may be colonized in vivo for a long time, and may be shift to cause bacterial infection.
