DPP-4 inhibitor Sig Leo Dean on the newly diagnosed type 2 diabetes mellitus and its effect on blood pressure and body weigh
10.3969/j.issn.1671-8348.2017.11.010
- VernacularTitle:DPP-4抑制剂西格列汀治疗新诊断老年2型糖尿病的疗效及其对血压、体质量的影响研究
- Author:
Yiqi CAI
;
Quan LV
;
Yingying WANG
;
Xicheng RUAN
;
Xibo JIN
- Keywords:
DPP-4 inhibitor;
Sig Leo Dean;
newly diagnosed;
diabetes mellitus,type 2;
blood pressure;
body weight;
aged
- From:
Chongqing Medicine
2017;46(11):1476-1477,1481
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of DPP-4 inhibitors in the treatment of newly diagnosed type 2 diabetes mellitus and its effect on blood pressure and body weight.Methods A total of 100 newly diagnosed elderly patients with type 2 diabetes mellitus were enrolled in this study from July 2013 to June 2015 in this hospital.They were divided into observation group and control group(n=50).The control group was treated with placebo on the basis of diet control and exercise.The observation group was treated with sitagliptin on the basis of diet control and exercise.Fasting plasma glucose(FPG),2 h postprandial blood glucose(2 h PG) and glycated albumin (GA) were measured before and after treatment,and the incidence rate of hypoglycemia,blood pressure,body weight and other adverse reactions were monitored.Results After treatment,two groups of patients,condition were significantly improved,FPG,2 h PG,GA changes in observation group were significantly better than that of control group,the difference were statistically significant(P＜0.05).There was no significant difference in blood pressure,body weight and body mass index before and after treatment,and also between the two groups(P＞0.05).The incidence of adverse reactions in the observation group and the control group were 10.0％ and 8.0％,The incidence of adverse reactions in the two groups was not statistically significant(P＞0.05).Conclusion The clinical efficacy of DPP-4 inhibitor siglitazide in the treatment of newly diagnosed elderly patients with type 2 diabetes mellitus is good,and it is very useful in the treatment of these patients.
