Significance of liver disease associated antibodies and biochemical detection in the diagnosis of patients with autoimmune hepatitis
10.3969/j.issn.1673-4130.2017.08.010
- VernacularTitle:肝病相关抗体和生化检测指标在自身免疫性肝炎诊断中的意义
- Author:
Xiaoyan WANG
;
Jiao LI
;
Qiyang SHI
;
Bing LI
- Keywords:
autoimmune hepatitis;
liver disease related antibodies;
determination of liver function
- From:
International Journal of Laboratory Medicine
2017;38(8):1038-1039,1042
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of autoantibodies and biochemical markers in the diagnosis of autoimmune hepatitis (AIH),and to provide the basis for clinical diagnosis.Methods AIH patients as AIH group(n=35),viral hepatitis as viral hepatitis group (n=30,including 9 cases of hepatitis A,15 cases of hepatitis B and 6 cases of hepatitis C),the other 33 healthy volunteers were selected as healthy control group,indirect immunofluorescence assay was used to detect ANA,ASMA,AMA.Western blot was used to detect SLA/LP,LC-1,LKM,AMA-M2 and biochemical examination means ALT,AST,ALP,gamma-GT,T-BIL,D-BIL,TBA.Results The test results of autoantibodies were tested by chi square test.The positive rate of ANA,ASMA,AMA and AMA-M2 in AIH group was significantly higher than that in viral hepatitis group and healthy control group (P<0.05).The results of biochemical test by rank sum test,ALP,gamma-GT in the AIH group was significantly higher than the other two groups (P<0.05).The results of D-BIL detection in viral hepatitis group were significantly higher than those in the other two groups (P<0.05).Conclusion The combination of autoantibodies and laboratory biochemistry could help clinical diagnosis of AIH.
