Correlation between serum zinc,selenium,chromium,copper and blood glucose levels in type 2 diabetes patients
10.3969/j.issn.1673-4130.2017.08.018
- VernacularTitle:2型糖尿病患者血清锌、硒、铬、铜与血糖水平的相关性研究
- Author:
Rensheng DU
;
Yongji YU
;
Weiming XIAO
- Keywords:
type 2 diabetes;
zinc;
selenium;
chromium;
copper;
insulin sensitivity;
oxidative stress
- From:
International Journal of Laboratory Medicine
2017;38(8):1059-1060,1063
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between levels serum zinc,selenium,chromium,copper and blood glucose in diabetic patients.Methods The 136 cases of type 2 diabetes were enrolled in our hospital during September 2013 to December 2015 in the observation group,and 136 cases of physical health in our hospital during the same period were recruited in the control group.Then the levels of serum zinc,selenium,chromium,copper contents and glycemic index,oxidative stress indicators were detected.Results The serum zinc,selenium content of the observation group were significantly lower than those in the control group(P<0.05),no significant difference were observed in the serum chromium,copper contents between two groups(P>0.05);the levels of FBG,2 h PBG,glycated hemoglobin,MDA,and HOMA-IR of observation group were higher than those of control group,the HOMA-β,I30/G30,SOD,GSH-Px levels were lower than those in the control group(P<0.05);the serum zinc,selenium contents were negatively correlated with FBG,2 h PBG,glycated hemoglobin,MDA levels,and HOMA-IR(P<0.05),while positively correlated with HOMA-β,I30/G30,SOD,GSH-Px(P<0.05).Conclusion Serum zinc,selenium contents in type 2 diabetes significantly decrease and closely be related with blood glucose levels,they can reduce blood sugar,promote insulin secretion,increase insulin sensitivity,and adjust the oxidative stress reaction.
