Comparison of the effects of different doses of methylprednisolone therapy for children with severe hand,foot and mouth disease
10.3760/cma.j.issn.1008-6706.2017.05.019
- VernacularTitle:不同剂量甲泼尼龙治疗小儿重症手足口病的临床效果比较
- Author:
Caihua LIU
;
Na YE
;
Yu WANG
;
Tiansheng CHEN
- Keywords:
Hand,Foot and Mouth Disease;
Methylprednisolone;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(5):714-716,717
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical effects of different doses of methylprednisolone therapy for children with severe hand,foot and mouth disease (HFMD).Methods According to different dosage methods, 240 children with severe HFMD were divided into large dose group,medium dose group and small dose group,80 cases in each group.The three groups were given different doses of methylprednisolone infusion on the basis of conventional treatment:large dose group(5 ~10mg·kg· -1 d -1 ),medium dose group(3 ~5 mg·kg· -1 d -1 ),small dose group (1 ~2mg · kg · -1 d -1 ).Results The time of fever sustaining,panic ease,mechanical ventilation,duration of hypertension and heart rate recovery of the medium -dose group were (47.93 ±4.72)h,(45.54 ±2.42)h,(51.43 ± 6.85)h,(53.66 ±7.62)h,(52.45 ±7.84)h,which were significantly shorter than those of the small -dose and large -dose group(all P <0.05).The incidence of turning to critically ill and the rate of ventilator use of the medium-dose group were significantly lower than those of the small -dose and large -dose group (all P <0.05 ).The incidence of pulmonary edema and pulmonary hemorrhage of the medium -dose group were significantly lower than those of the small -dose and large -dose group(all P <0.05).The differences among three groups were not statistically significant in the complications such as hypokalemia,hypocalcemia and gastrointestinal bleeding (all P >0.05 ). Conclusion Medium dose of methylprednisolone in the treatment of children with severe HFMD has significant effect and less adverse reactions,which is worthy of promotion.
