Expression significance of cellular inhibitor of apoptosis proteins 2 in patients with hepatitis B related HCC
10.3969/j.issn.1671-8348.2017.10.016
- VernacularTitle:细胞凋亡蛋白抑制因子2在乙型肝炎相关性肝癌患者中的表达意义
- Author:
Linfeng LI
;
Lijuan CUI
;
Zhi LIU
;
Qin XIA
;
Haiyin QIN
;
Jiao HE
- Keywords:
carcinoma,hepatocellular;
hepatitis virus,type B;
cellular inhibitor of apoptosis proteins 2
- From:
Chongqing Medicine
2017;46(10):1349-1351,1354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of cellular inhibitor of apoptosis proteins 2 (cIAP2) expression in the patients with hepatitis B and non-hepatitis B related hepatocellular carcinoma (HCC).Methods The medical record data and tissue samples in the patients with HCC resection operation were collected.Expression of cIAP2 in HCC cancer lesion,adjacent tissues and cancer-distant tissues was detected by immunohistochemical staining and Western blotting.Results In the cancer lesion,paracancerous tissues and cancer-distant tissues of the two groups,the cIAP2 expression amount was decreased in turn.But in the non-hepatitis B related HCC group,the cIAP2 expression in the cancer-distant tissues was significantly lower than that in the HCC cancer lesion and paracancerous tissues,while in the hepatitis B related HCC group,the cIAP2 expression amounts had no significant difference between the caner-distant tissues and paracancerous tissues,while lower than that in the cancer lesion.Conclusion cIAP2 is one of important mechanisms causing hepatic B related HCC and can serve as a therapeutic target point for inhibiting HCC development and eliminating hepatitis B virus.
