Role of myeloid-derived suppressor cells in autoimmune disease
10.3969/j.issn.1000-484X.2017.03.001
- VernacularTitle:MDSC在自身免疫疾病中的作用
- Author:
Hao WU
;
Huanfa YI
;
Yongguang YANG
- Keywords:
MDSC;
Autoimmune disease;
Th17 differentiation
- From:
Chinese Journal of Immunology
2017;33(3):321-327,332
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cells ( MDSC) are a bone marrow-derived heterogeneous cell population with immuno-suppressive activity.Although there is convincing evidence that autoimmune diseases are associated with MDSC expansion ,controversies remained regarding the role of MDSCs in controlling autoimmune responses .Recent studies have shown that the expansion of MDSCs , which are capable of inhibiting effector cell function in vitro ,does not always lead to alleviation of autoimmune diseases ,and in some ca-ses paradoxically exacerbates the disease progression .This review summarizes recent insights into the role of MDSCs in the development of autoimmune responses and the potential of using MDSCs for the treatment of autoimmune diseases .
