Expression of tumor stem cell markers Lgr5 and CD44 in esophageal carcinoma and its clinical significance

VernacularTitle:肿瘤干细胞标志物Lgr5和CD44在食管癌中的表达及临床病理意义
Author: Haifei ZHAO ; Jianwen ZHOU ; Yiping XU
Keywords: Lgr5; CD44; esophageal cancer; correlation
From: Chinese Journal of Biochemical Pharmaceutics 2017;37(1):296-297,301
CountryChina
Language:Chinese
Abstract: Objective To analyze the expressions of tumor stem cell markers Lgr5 and CD44 in esophageal carcinoma and its clinical pathological significance.Methods A total of 108 cases of patients with esophageal cancer, 35 cases of stage Ⅱ, 40 cases of stage Ⅲ, 4 cases of stage Ⅳ. After tumor specimens were stained, the expressions of Lgr5 and CD44 in esophageal cancer tissue were detected and its relationship with the clinical features were analyzed.Results There were relations between expressions of Lgr5 and CD44 in esophageal cancer tissue and clinical staging, the later the stageing, the higher expression rate of Lgr5 and CD44, but there was no significant differece with Chi-square test. The Spearman correlation analysis showed there was no correlation between Lgr5 or CD44 and esophageal cancer condition. Conclusion CD44 and Lgr5 are highly expressed in esophageal cancer tissue, but the correlation between CD44 and Lgr5 expression and esophageal cancer condition is uncertain.