Expression of 14-3 -3 protein in the cervical cancer patients and its clinical significance
10.3760/cma.j.issn.1008-6706.2017.06.009
- VernacularTitle:14-3-3蛋白在宫颈癌组织中的表达及其意义
- Author:
Qiaoyun ZHAO
;
Guangmin FAN
;
Zhengying RUAN
;
Xianglan YING
- Keywords:
Uterine cervical neoplasms;
CCN intercellular signaling proteins;
Immunohistochemistry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(6):834-836,837
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential roles of 14 -3 -3 in the pathogenesis of the cervical cancer.Methods Tissues from 107 patients with cervical cancer(cervical cancer group),50 cases of cervical intra-epithelial neoplasia (cervical intraepithelial neoplasia group)and 50 cases of chronic cervicitis (chronic cervicitis group)were obtained.Immunohistochemistry was performed to determine the expression of 14 -3 -3 protein in tissues of the three groups.Results The positive rate of 14 -3 -3 in cervical cancer group(75.70%)was signifi-cantly higher than that in cervical intraepithelial neoplasia group and chronic cervicitis group(42.00%,30.00%, respectively)(χ2 =17.00,29.96,all P <0.01),while there was no significant difference of 14 -3 -3 level between the cervical intraepithelial neoplasia group and chronic cervicitis group(χ2 =1.56,P >0.05).Moreover,in the cervi-cal cancer group,the positive rate of 14 -3 -3 in lymph node metastasis group was 88.89%,which was higher than that in negative lymph node metastasis group (63.16%)(χ2 =5.15,P <0.05).Conclusion The expression level of 14 -3 -3 protein in cervical cancer is increased,it may be correlated with cervical cancer cell malignant differenti-ation and metastasis.Perhaps,14 -3 -3 will play a key role as a novel target for tumor therapy.
