Analysis of the Characteristics and Gene Relationship of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Induced by Oxcarbazepine

VernacularTitle:奥卡西平致Stevens-Johnson综合征和中毒性表皮坏死松解症的特点及基因相关性分析
Author: Chen CHEN ; Yi JIANG ; Shaojun SHI ; Yihui LIU
Keywords: Oxcarbazepine; Stevens-Johnson syndrome; Toxic epidermal necrolysis; HLA-B*1502 gene
From: China Pharmacy 2017;28(5):620-624,625
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To investigate the clinical characteristics and gene polymorphism of oxcarbazepine (OXC)- induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). METHODS:Retrieved from CNKI,Wanfang,VIP, PubMed,EMBase,SpringerLink and other databases,case reports about OXC-induced severe ADR were summarized and ana-lyzed. RESULTS:Twelve literatures were collected,and 13 case reports about OXC-induced SJS/TEN were obtained. Male had more OXC-induced severe skin ADR than female. ADR mostly occurred during 1-14 d after medication. All patients were cured with treatment of glucocorticoid and antiallergy,without death case. Genotyping for 8 patients were performed and 6 of them showed the presence of HLA-B*1502 allele. While HLA-B alleles of 2 patients were HLA-B*1518/B*4001,which was the variation of HLA-B*1502. CONCLUSIONS:OXC-induced ADR should be monitored closely. Great importance should be attached to patient education and follow-up program. HLA-B*1502 gene detection should be performed to guide rational use of OXC and optimize clini-cal drug use plan.