Clinical Study of Bencycloquidium Bromide Nasal Spray in the Treatment of Rhinitis after Cold
10.6039/j.issn.1001-0408.2017.05.29
- VernacularTitle:苯环喹溴铵喷鼻剂治疗感冒后急性鼻炎的临床研究
- Author:
Caixia LI
;
Zhongying MA
;
Changgui WU
;
Zhikui LI
;
Chuntao LIU
;
Yamei WU
;
Qinglin HAO
;
Xiaowen HAN
;
Xueyu ZHANG
- Keywords:
Bencycloquidium bromide nasal spray;
Cold;
Acute rhinitis;
Rhinorrhea score
- From:
China Pharmacy
2017;28(5):680-682,683
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the effects and safety of Bencycloquidium bromide nasal spray in the treatment of acute rhinitis after a cold. METHODS:A multicenter,dose parallel controlled,randomized,double-blind,placebo-controlled clinical tri-al was conducted. Two hundred and thirty-eight patients with acute rhinitis after a cold were selected and divided into group A(24 cases),B(24 cases),C(24 cases),D(24 cases),E(23 cases),F(24 cases),G(23 cases),H(24 cases),I(24 cases),J (24 cases). Group A-C were given Bencycloquidium bromide nasal spray 22.5μg,45μg,90μg,respectively,bid,spraying it once for each nostril. Group D-F were given Bencycloquidium bromide nasal spray 22.5 μg,45 μg,90 μg,respectively,tid,spraying it once for each nostril. Group G-I were given Bencycloquidium bromide nasal spray 22.5 μg,45 μg,90 μg,respectively,qid,spray-ing it once for each nostril. Group J was given placebo. All groups were treated for(4±1)d. Rhinorrhea score and continuous rhi-norrhea duration were compared among 10 groups,and the safety was evaluated. RESULTS:The rhinorrhea score and continuous rhinorrhea duration of 10 groups were improved significantly,with statistical significance (P<0.05). The improvement and trend of group I was slightly better than other 9 groups,without statistical significance(P>0.05). There was no statistical significance in the incidence of ADR among 10 groups(P>0.05). CONCLUSIONS:Bencycloquidium bromide nasal spray with 90 μg,qid times significantly improves rhinorrhea score and continuous rhinorrhea duration with good safety.
