Chemical constituents from the heartwood of Trachycarpus fortunei (Hook.) H. Wendl
10.7644/j.issn.1674-9960.2017.01.014
- VernacularTitle:棕树心化学成分研究
- Author:
Lili GUI
;
Li CHEN
;
Junxing DONG
- Keywords:
Trachycarpus fortunei ( Hook.) H. Wendl.;
plant extracts;
chemical constituents;
structural identification;
drug screening assays,antitumor
- From:
Military Medical Sciences
2017;41(1):62-64,76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents of the heartwood of Trachycarpus fortunei.Methods Compounds were isolated and purified by silica gel column , Sephadex LH-20 chromatography and recrystallization .Their structures were elucidated by physicochemical properties and spectral data .Results Ten compounds were isolated from the 95%ethanol extract of the heartwood of T.fortunei and identified as 1,3-dihydroxyanthraquinone (1),mollugin(2), 4-hydroxy-2, 6-dimethoxy-benzoic acid ( 3 ), 5-hydroxy-2-hydroxymethyl-γ-pyranone ( 4 ), 3, 5-dihydroxy-2-methyl-γ-pyranone(5),3,5-dihydroxy-γ-pyranone (6),daucosterol (7),4-hydroxybenzoic acid (8),pyrocatechol (9),β-sitosterol (10).Conclusion Compounds 1-7 have been obtained from this plant for the first time ,and 1-6 from the genus for the first time.The screening results of antitumor activity in vitro show that the half inhibitory concentration IC 50 of compound 2 for human osteosarcoma cells U20S and human neuroblastoma cells SY 5Y is 18.10 and 26.59 μg/ml respectively. Compound 5 can inhibit the growth of human breast cancer cells MCF-7 with a half inhibitory concentration IC 50 of 37.31μg/ml.
