Effects of Using Oxycodone Hydrochloride before Abdominal Closure on Hemodynamics and Sedation in Gynecological Patients Underwent General Anesthesia of Laparoscopic Surgery
10.6039/j.issn.1001-0408.2017.05.25
- VernacularTitle:关腹前应用盐酸羟考酮对全身麻醉下妇科腹腔镜手术患者血流动力学及镇静作用的影响
- Author:
Nijuan LI
;
Wei WU
- Keywords:
Oxycodone;
Laparoscopic surgery;
General anesthesia;
Analgesia;
Recovery
- From:
China Pharmacy
2017;28(5):667-669,670
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of using oxycodone hydrochloride before abdominal closure on hemodynam-ics and sedation in gynecological patients underwent general anesthesia of laparoscopic surgery. METHODS:Eighty-two patients un-dergoing gynecological laparoscopic surgery were selected and divided into control group and observation group according to treat-ment order,with 41 cases in each group. Both group were operated under general anesthesia with endotracheal intubation. Observa-tion group was given oxycodone hydrochloride intravenously 3 mg,and control group was given constant volume of 0.9% Sodium chloride injection before abdominal closure. SBP,HR and Ramsay score were observed in 2 groups during extubation(T1),5 min after extubation(T2),30 min after extubation(T3). The spontaneous breathing recovery time,recovery time,extubation time and the occurrence of cough and agitation were recorded in 2 groups. 2,4,6 and 24 h after surgery,VAS scores were determined in 2 groups. The occurrence of ADR was observed in 2 groups. RESULTS:At T1 and T2,there was no statistical difference in SBP and HR between 2 groups (P>0.05);at T3,SBP and HR of control group were significantly increased and higher than observation group,with statistical significance(P<0.05);At T1,there was no statistical significance in Ramsay score between 2 groups(P>0.05);at T2 and T3,Ramsay score of observation group was significantly improved and higher than control group,with statistical significance (P<0.05). There was no statistical significance in extubation time between 2 groups (P>0.05). The spontaneous breathing recovery time and recovery time of observation group were significantly shorter than control group,with statistical signifi-cance(P<0.05). The incidence of no cough and agitation at 0 level in observation group were significantly higher than in control group;and the incidence of median and severe cough,agitation at 2-3 level were significantly lower than control group,with statis-tical significance(P<0.05). 2 h,4 h,6 h and 24 h after operation,VAS scores of observation group were significantly lower than control group,with statistical significance (P<0.05). The incidence of ADR in observation group was 7.3%,which was signifi-cantly lower than 51.2% of control group,with statistical significance(P<0.05). CONCLUSIONS:The application of oxycodone hydrochloride before abdominal closure shows good analgesic and sedative effects in gynecological laparoscopic surgery under gener-al anesthesia with good safety,can keep hemodynamics stable and quick recovery.
