Efficacy and adverse reaction of total glucosides of paeony compared with vitamin B2 in recurrent aphthous ulcers

VernacularTitle:白芍总苷对比维生素B2治疗复发性阿弗他溃疡的疗效及不良反应
Author: Xufei YAO ; Yu JI ; Zhemin WU
Keywords: total glucosides of peony; vitamin B2; recurrent aphthous ulcers (RAU)
From: Chinese Journal of Biochemical Pharmaceutics 2017;37(1):66-67,70
CountryChina
Language:Chinese
Abstract: Objective To explore and analyze the clinical efficacy and adverse reactions of total glucosides of paeony (TGP) and vitamin B2 in the treatment of recurrent aphthous ulcers (RAU) . Methods 120 patients of RAU were randomly divided into TGP group and vitamin B2 group, 60 cases in each group. The TGP group received TGP capsules after meals, three times a day, 0.6g/d. Vitamin B2 group received vitamin B2 tablets, three times a day, 5mg/d, 8 weeks for one course. The ulcer change, visual analogue scale (VAS) and efficacy were observed. Results After treatment, the VAS scores were significantly reduced in two groups(P<0.05), and the above indicators of TGP group were better than vitamin B2 group(P<0.05). The total efficacy in TGP group was higher than that in vitamin B2 group (P<0.05). There was minor adverse reactions in TGP group and no significant adverse reactions in vitamin B2 group.Conclusion TGP has good efficacy and safety in the treatment of recurrent aphthous ulcers. The TGP has significant effect than that of vitamin B2.