Protective effect of Shen Mai injection in the treatment of lung injury induced by radiotherapy in patients with advanced breast cancer
10.3969/j.issn.1005-1678.2017.01.025
- VernacularTitle:参麦注射液对乳腺癌晚期放疗肺损伤的保护作用研究
- Author:
Weiyue HE
;
Qilun LU
;
Changjing HUANG
- Keywords:
Shen Mai injection;
breast cancer;
lung function;
T lymphocyte subsets
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(1):94-96,100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of Shen Mai injection in the treatment of lung injury induced by radiotherapy in patients with advanced breast cancer. Methods 80 cases with lung injury induced by radiotherapy in patients with advanced breast cancer from our hospital from 2015.1 to 2016.5 were selected and randomly divided into 2 groups, 40 cases in control group were given routine treatment, 40 cases in the experimental group were treated based on the control group treated with Shenmai injection treatment, and 2 groups were treated for 4 weeks. The pulmonary function, T lymphocyte subsets, clinical symptoms, quality of life scores and clinical efficacy were observed before and after treatment in two groups. The results were analyzed by statistical software SPSS 19.0. Results Compared with before treatment, levels of FVC, FEV1 and TLC in 2 groups after treatment elevated, scores of respiratory symptoms, activities, and daily life effect decreased, levels of serum CD3+, CD4+, CD4+/CD8+elevated, levels of CD8+ decreased, and compared with the control group, levels of FVC, FEV1, TLC, CD3+, CD4+, CD4+/CD8+ in the experimental group were higher, scores of respiratory symptoms, activities, and daily life effect were lower, clinical effect rate was higher, the differences were statistically significant (P<0.05). Conclusion Shen Mai injection can effectively improve lung function and immunity, improve respiratory symptoms and improve the quality of life in patients with advanced breast cancer radiotherapy for lung injury, and has better clinical efficacy.
