Effect of 17β-estradiol on idiopathic ventricular arrhythmia and IP3/Ryn 2 expression of receptor-regulated calcium pool during peri-menopausal period
10.3969/j.issn.1005-1678.2017.01.041
- VernacularTitle:17β-雌二醇治疗围绝经期特发性室性心律失常疗效及对钙离子库受体IP3/Ryn 2基因表达的影响
- Author:
Ling TONG
;
Xianjiang WEI
;
Chunxiang LIN
- Keywords:
17β-estradiol;
peri-menopausal period;
idiopathic ventricular arrhythmia;
IP3;
Ryn 2
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(1):145-146,150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the curative effect of 17β-estradiol on idiopathic ventricular arrhythmia (IVA) during peri-menopausal period and explore the association with IP3/Ryn expression of receptor-regulated calcium pool. Methods 32 cases IVA during peri-menopausal period (IVA group) and 32 cases healthy women during peri-menopausal period of the same levels of age (normal control group) were selected. The IVA group received oral 17β-estradiol for 2 months. The count of arrhythmia in IVA group was recorded, the IP3/Ryn 2 expression pre- and post-treatment in IVA group and normal control group were detected. Results Compared with pre-treatment, 17β-estradiol significantly reduced the occurrence of IVA (P<0.05). Compared with pre-treatment, 17β-estradiol significantly reduced IP3 expression(P<0.05), while there was no significant difference compared with normal control group. 17β-estradiol had no significant effect on Ryn 2 expression. Conclusion The anti-IVA effect of 17β-estradiol may be associated with the IP3 receptor gene expression.