CT features of renal carcinoma associated with xp11 .2 translocations/TFE3 genes fusions

VernacularTitle:Xp11.2易位/TFE3基因融合相关性肾细胞癌的CT表现
Author: Bing SHAO ; Yonggao ZHANG ; Jianbo GAO
Keywords: Xp11 .2; renal cell carcinoma; computed tomography
From: Journal of Practical Radiology 2017;33(3):415-417,421
CountryChina
Language:Chinese
Abstract: Objective To analyze the CT features of renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions (Xp11.2 RCC),and to improve the diagnostic accuracy.Methods Clinical data,CT imaging and pathological features of 12 cases with pathology proved Xp11.2 RCC were analyzed retrospectively.Results All the 12 cases were solid masses.11 cases were oval or quasi-circular,1 case was irregular.Tumors were iso-density or hyperdensity on CT plain scan images.The density was heterogene-ous,combined with necrosis in 11 cases and spotty or patchy calcification in 7 cases.After injection of contrast,moderate or obvious enhancement of tumors was found,1 case had retroperitoneal lymph node metastasis,1 case was found with mass formation in the re-nal hilus,1 case had adrenal metastasis.Another one was found with psoas major muscle and lumbar 5 invaded.Conclusion The Xp11 .2 RCC has certain CT characteristics.This disease should be considered when a renal tumor is iso-density or hyperdensity on the CT plain scan images and has moderate or obvious enhancement,combined with necrosis or calcification.