Clinical significance of combined detection of D-dimer and Cys-C in nephrotic syndrome
10.3969/j.issn.1671-8348.2017.07.010
- VernacularTitle:D-二聚体和Cys-C联合检测在肾病综合征中的临床意义
- Author:
Haiying DAI
;
Hongliang WANG
;
Yan LI
- Keywords:
nephrotic syndrome;
D-dimer;
cystatin C
- From:
Chongqing Medicine
2017;46(7):896-897,900
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of combined detection of D-dimer,PT,FIB and Cyc-C in the patients with nephrotic syndrome(NS) complicating thromboembolism.Methods Sixty-five patients with clinically diagnosed NS(observation group) in the Huangshi Municipal Central Hospital from April 2013 to March 2016 were selected and divided into the non-thromboembolism group(group A,45 cases) and thromboembolism group(group B,20 cases).Contemporaneous 43 individuals undergoing physical examination served as the control group(group C).The levels of Cys-C and 24 h urine protein were tested by the electrochemical luminescence method;meanwhile PT,FIB and D-dimmer levels were detected by the nephelometry method.Their changes in the patients with NS complicating thromboembolism were observed.Results The levels of Cys-C,24 h urine protein and D-dimer in the observation group were significantly higher than those in the control group (P＜0.01).The difference of PT and FIB levels were not statistically significant(P＞0.05);the D-dimer and Cys-C levels in the observation B group was significantly higher than that in the observation A group(P＜0.05),moreover the D-dimer level was positively correlated with Cys-C.Conclusion D-dimer and Cys-C can be used as the predictive factors of thromboembolism occurrence in NS patients.
