Efficacy of prostaglandin E1 in sepsis patients and its influence on inflammatory level
10.3969/j.issn.1671-8348.2017.07.020
- VernacularTitle:前列腺素E1对脓毒症患者疗效及炎症水平的影响
- Author:
Bingxin DONG
;
Lujun QIAO
- Keywords:
alprostadil;
Xuebijing injection;
sepsis
- From:
Chongqing Medicine
2017;46(7):929-930,933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of prostaglandin E1 on proinflammatory and anti-inflammatory cytokines in sepsis patients.Methods One hundred and twenty cases of sepsis in ICU of our hospital were assigned to the groups:A,B,C and D,30 cases in each group.On the basis of conventional therapy,group A was added with prostaglandin El+ Xuebijing injection.The group was treated with prostaglandin E1,while the group C was treated with Xuebijing injection.The changes of APACHE Ⅱ score,Marshall score,anti-inflammatory and pro-inflammatory factors,mechanical ventilation time,ICU treatment time,28 d mortality rate in the 4 grups were observed and compared among 4 groups.Results The APACHE Ⅱ score and Marshall score after treatment in 4 groups were significantly decreased compared with before freatment (P＜0.05),Compared with the group B,C and D,The decrease of APACHE Ⅱ score,Marshace score,IL-1β,IL-6 and TNF-α levels was more significantly(P＜0.05),While the IL-10 level was significantly increastol(P＜0.05);duration of mechanical ventilation,length of stay ICU in were significantly shorter (P＜0.05),28 d mortality was significantly lower (P＜0.05).Conclusion Prostaglandin E1 combined with Xuebijing injection can effectively inhibit the inflammatory response in septic patients and promote the recovery of patients,reduces the mortality rate.
