Effect of Qizhen capsule combined with docetaxel injection on neoadjuvant chemotherapy in patients with breast cancer and its safety evaluation
10.3969/j.issn.1005-1678.2017.03.043
- VernacularTitle:芪珍胶囊联合多西他赛注射液对乳腺癌患者新辅助化疗的效果及安全性评价
- Author:
Yidi HU
;
Shenxia XIE
;
Hui ZHANG
;
Qiongyao LI
;
Weiyan JIANG
- Keywords:
Qizhen capsule;
docetaxel injection;
breast cancer;
neoadjuvant chemotherapy
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(3):144-146,149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Qizhen capsule combined with docetaxel injection on the neoadjuvant chemotherapy of breast cancer and its effects on cyclooxygenase (COX-2), cancer antigen 15-3 (CA15-3),and vascular endothelium growth factor (VEGF).Methods 84 patients with breast cancer were selected in our hospital from January 2015 to August 2016, those patients were divided into observation group and control group according to coin method.The control group received docetaxel injection, epirubicin injection, cyclophosphamide neoadjuvant chemotherapy, the observation group was treated with Qizhen capsule on the basis of the control group.The clinical efficacy, COX-2, CA15-3 and VEGF levels, quality of life and adverse reactions were compared between the two groups.Results After treatment, the total effective rate in the observation group (90.48%) was significantly higher than the control group (57.14%) (P<0.05).After treatment, the levels of COX-2, CA15-3 and VEGF in the observation group were significantly lower than the control group (P<0.05).The scores of cognitive function, emotional function, social function, role function and physical function of life quality in the observation group were significantly higher than the control group ( P<0.05 ) .Cardiac toxicity, nausea and vomiting, thrombocytopenia, alopecia, neutropenia and leukopenia were significantly lower in the observation group than the control group (P<0.05). Conclusion Qizhen capsule combined with docetaxel injection can significantly reduce the levels of COX-2, CA15-3 and VEGF in the neoadjuvant chemotherapy of breast cancer, and the clinical curative effect is good, which can effectively improve the quality of life of patients and reduce the adverse reaction rate.
