Limb remote ischemic preconditioning attenuates lung injury in patients during one-lung ventilation
10.3969/j.issn.1671-8348.2017.06.014
- VernacularTitle:肢体远隔缺血预处理减轻单肺通气时患者的肺损伤
- Author:
Zhentao SUN
;
Ning WANG
;
Yanan CAO
;
Xueqing SUN
;
Xueping HAN
;
Suen REN
- Keywords:
extremities;
ischemic preconditioning;
pulmonary ventilation;
acute lung injury;
lung protection
- From:
Chongqing Medicine
2017;46(6):764-766,769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of remote ischemic preconditioning (RIPC) on the lung injury during one-lung ventilation (OLV) in the patients undergoing thoracic surgery.Methods Eighty patients scheduled for elective radical operation for esophageal cancer,were randomly divided into 2 groups (n=40 each) using a random number table.control group (group C) and group RIPC.At 0 (T1),30 min (T2),1 h (T3) and 2 h (T4) of OLV,blood samples were obtained from the radial artery for blood gas analysis and determination of plasma concentrations of tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1ββ) and IL-10.Oxygenation index(OI),respiratory index(RI) and PaO2/PAO2 were calculated.Exhaled breath condensate was collected and the pH value was measured.Results Compared with group C,Oxygenation index was significantly increased,and respiratory index was decreased at T2-T4,the plasma concentrations of TNF-α and IL-1β were decreased,and the pH value of exhaled breath condensate was increased at T3-T4,and the plasma concentration of IL-10 was increased at T4 in group RIPC.Conclusion RIPC can inhibit inflammatory responses and reduce airway acidification,thus attenuating the lung injury during OLV in the patients undergoing thoracic surgery.
