Meta-analysis of the relevance between Megsin rs1055901 ,rs1055902 and rs2689399 polymorphism and susceptibility of IgA nephrology in Asian population
10.3969/j.issn.1671-8348.2017.05.022
- VernacularTitle:Megsin基因3个多态性位点与亚洲人群IgA肾病易感性关联的Meta分析
- Author:
Yating GE
;
Meiling SU
;
Jiazhi SONG
;
Zuying XIONG
;
Shuang HOU
- Keywords:
glomeruloneohritis,IgA;
disease susceptibility;
linkage disequilibrium;
Megsin;
polymorphism;
Meta-analysis
- From:
Chongqing Medicine
2017;46(5):648-650,653
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the association of three polymorphisms in Megsin (rs1055901,rs1055902 and rs2689399) and susceptibility of IgA nephropathy in Asian population.Methods We conducted a comprehensive search of electronic CNKI,VIP,WangFang Data,CBM,Pubmed,Web of Science and Google Scholar database on the association between Megsin rs1055901,rs1055902 and rs2689399 polymorphism and susceptibility of IgA nephrology in Asian population (last search update on 2 May 2016).Stata 12.0 software was used to calculate the odds ratio (OR) and 95 ％ CI (confidence interval),as well as sensitivity and publication bias analyses.Results Six publications encompassing mine case-control studies were finally included,including 2 179 cases and 1 769 controls.Finally,no significant association between Megsin rs1055901 and rs1055902 polymorphism and IgA nephrology in Asian population was identified,while a significantly decreased risk of IgA nephrology for rs2689399 polymorphism,was identified in Asian population (G and C:OR=0.754,95％CI 0.592-0.961,P=0.022;GG and CC:OR=0.506,95％CI 0.287-0.892,P=0.019;GG and GC+CC:OR=0.551,95％CI 0.316-0.961,P=0.036).Conclusion Rs2689399 G allele and GG genotype of Megsin may be the protective factors for IgA nephropathy in Asian population.
