The research progress of bile acid efflux pump (BSEP)
10.3969/j.issn.1001-1978.2017.01.004
- VernacularTitle:胆酸盐外排泵研究的最新进展
- Author:
Jing ZHAO
;
Manyu CHEN
;
Lei LI
- Keywords:
BSEP;
cholestasis;
inhibitor;
regulation;
bile acid;
regulatory factor
- From:
Chinese Pharmacological Bulletin
2017;33(1):18-21,22
- CountryChina
- Language:Chinese
-
Abstract:
Bile acid efflux pump(BSEP)is the major transporter of bile salts secreted by liver cells into the bile,the variation and inhibition of which are connected with cholestasis and drug-induced liver injury.A deep understanding of the physiological and pathological function of BSEP IS achieved by analysis and summary of diseases.The paper briefly illustrates the structure, expression,regulation,substrates,inhibitors and diseases of BSEP,in order to provide further theoretical and experimental basis for the clinical treatment.
