Vitamin D status among neonates and its impact on lung maturation
10.3760/cma.j.issn.1673-4408.2016.12.011
- VernacularTitle:维生素D缺乏与新生儿肺发育
- Author:
Jun CHEN
;
Bin WANG
- Keywords:
Vitamin D;
Neonates;
Lung development
- From:
International Journal of Pediatrics
2016;43(12):942-944,945
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies show that vitamin D plays a role in lung development and regulation of lung maturation in the fetus. The AAP and the Institute of Medicine( IOM) both define vitamin D insufficiency as ser-um 25-OH-D concentrations <50 nmol/L in the pediatric population. The surveys in our country show the prev-alence of vitamin D insufficiency is higher according to the criteria defined by AAP. Evidence from animal study suggests that vitamin D may increase alveolar count,alveolar septal thickness,lung volume and decrease airway resistance,immune cell aggregation leading to the maturation of lung. The cohort studies suggest low 25-OH-D level in infants at birth is associated with greater need for assisted ventilation,increased rate of ARDS,increased duration of oxygen requirement.
