New therapeutic strategies for eradication of Helicobacter pylori in children

VernacularTitle:儿童中根除幽门螺杆菌新的治疗对策
Author: Yi CHEN ; Jie CHEN
Keywords: Helicobacter pylori; Eradication rate; Sequential therapy; Bismuth-based therapy; Concomi-tant therapy; Probiotics
From: International Journal of Pediatrics 2016;43(12):905-908,909
CountryChina
Language:Chinese
Abstract: Helicobacter pylori is closely related to many digestive system diseases,such as chronic gas-tritis,digestive ulcer,gastric mucosa associated lymphoid tissue lymphoma and gastric cancer,also leads to chil-dren with iron deficiency anemia,growth retardation,asthma,allergic diseases etc. So it is a key strategy to pre-vent and treat these diseases by eradicating Helicobacter pylori. Due to the increasing rates of antimicrobial resist-ance of clarithromycin and metronidazole,the eradication rate of standard triple therapy is 1ess than 80%in re-cent years. Especially in areas of high clarithromycin resistance and standard triple therapy have not been recom-mended as first-line therapy,it is necessary to investigate a new therapeutic strategy to improve the eradication rate of Helicobacter pylori. The new treatments for eradication of Helicobacter pylori in children is mainly based on sequential therapy,bismuth-based therapy,concomitant therapy and probiotics treatment. This article reviews the research progress of the new treatments in recent years.