Effects of intraperitoneal injection of 5-HT2A receptor antagonist MDL11939 on acute and chronic pain in mice
10.3969/j.issn.1001-1978.2017.02.016
- VernacularTitle:腹腔注射5-HT2A 受体拮抗剂MDL11939对小鼠急性及慢性疼痛的影响
- Author:
Siting HUANG
;
Ningning JI
;
Lei DU
;
Gongliang ZHANG
;
Yongmei ZHANG
- Keywords:
5-HT2A receptor;
MDL1 1 939;
visceral pain;
sciatica;
incision pain;
CCI
- From:
Chinese Pharmacological Bulletin
2017;33(2):223-226,227
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects and signifi-cance of 5-HT2A receptor antagonist MDL1 1 939 on a-mice.Methods Kunming male mice were suffered a-cute acetic acid visceral pain,acute incision pain and CCI neuropathic pain.After each animal model was es-tablished,MDL1 1 939 was injected intraperitoneally. The writhing reaction was used to assess acute acetic acid visceral pain,while the thermal withdrawal laten-cy (TWL)was used to evaluate the acute incision pain and CCI neuropathic pain.Results Compared with the control group,MDL1 1 939 (0.25,0.5,1 .0 mg· kg -1 ,i.p.)relieved acetic acid visceral pain signifi-cantly in a dose-dependent manner in mice,as re-vealed by the significant reduction of the number of twisting.In acute incision pain and CCI neuropathic pain,MDL1 1 939 (0.5 mg·kg -1 ,i.p.)significantly increased TWL level.Conclusion 5-HT2A receptor antagonist MDL1 1 939 has analgesic effects on visceral pain,acute pain and neuropathic pain,which might be a novel therapeutic target to treat different pain in clini-cal situations.
