Roles of liver sinusoidal endothelial cells in liver diseases
10.3969/j.issn.1001-1978.2017.02.001
- VernacularTitle:肝窦内皮细胞在肝脏疾病中的作用
- Author:
Chenxi ZHANG
;
Mianli BIAN
;
Xingran CHEN
;
Shifeng ZHAO
;
Huanhuan JIN
;
Qin CHEN
;
Feng ZHANG
;
Shizhong ZHENG
- Keywords:
LSECs;
capillarization;
NAFLD;
AFL;
HCC;
liver re-generation;
liver fibrosis
- From:
Chinese Pharmacological Bulletin
2017;33(2):149-152,153
- CountryChina
- Language:Chinese
-
Abstract:
Liver sinusoidal endothelial cells (LSECs) are the highest proportion of liver non-parenchymal cells with fenestrae structure and high endocytic ability maintaining liver homeostasis and playing an indispensable role in the physiology and patholo-gy of the liver.LSECs are involved in the regulation of patholog-ical process in nonalcoholic fatty liver disease(NAFLD),alco-holic fatty liver(AFL),hepatocellular carcinoma(HCC),liverregeneration and liver fibrosis mainly via antiinflammation,endocytosis,secretion of angiocrine signals and maintaining thequiescence phenotype of HSCs.This review highlights the physiological function of LSECs and the different roles in different pathological conditions,which aims to provide a new perspectivefor the treatment of liver diseases through targeting LSECs.
