The Relationship between vitamin D and bone metabolism markers in osteoporosis patients of Chongqing
10.3969/j.issn.1673-4130.2017.02.007
- VernacularTitle:重庆地区骨质疏松患者25-羟维生素D与骨代谢的相关性分析
- Author:
Hua ZHOU
;
Qing ZHAO
;
Nianling XIE
;
Weixian CHEN
- Keywords:
osteoporosis;
25-hydroxy vitamin D;
bone metabolism;
correlation
- From:
International Journal of Laboratory Medicine
2017;38(2):163-165,171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the statistical correlation between 25-hydroxyl vitamin D and bone metabolism parameters in-cluding parathyroid hormone(PTH),N-terminal osteocalcin (N-MID),calcitonin(CT),bone alkaline phosphatase(BALP),and dis-cuss the significance in clinical diagnosis,prevention and treatment.Methods 411 cases of hospitalized patients were collected from January to September in 2014,including 316 women,95 men,age arranged from 37 to 96,the average age was(69.29±12.21).Use electro chemiluminescence immunoassay(ECLIA)method to detect the levels of 25-hydroxyl vitamin D,PTH,N-MID,CT,and BALP in hospitalized patients and explore the relationship of 25-hydroxyl vitamin D and serum bone markers in osteoporosis pa-tients.Results It was showed that vitamin D and PTH,BALP were negative correlation(P <0.05);There was no significant corre-lation between calcitonin and N-terminal osteocalcin(N-MID)(P >0.05 ).Regression analysis showed that regression equation for vitamin D and blood bone markers was:Y =19.02-0.066PTH-0.09BALP.Conclusion There was some correlation between 25-hydroxyl vitamin D and PTH,BALP in patients with osteoporosis.By taking a combination test of these markers,it can provide some basic data for clinical osteoporosis diagnosis,prevention and control.
