Changes and clinical correlation of serum IL-4 level for patients with chronic hepatitis B
10.3969/j.issn.1673-4130.2017.02.011
- VernacularTitle:HBV 感染者 IL-4水平变化及与临床的相关性
- Author:
Caidong LI
;
Yongwei YANG
;
Xilian CHEN
;
Pengfei TIAN
;
Zhengjun DUAN
;
Xuemei LIU
- Keywords:
HBV infection;
interleukin-4;
HBV DNA;
clinical correlation
- From:
International Journal of Laboratory Medicine
2017;38(2):177-178,181
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and clinical correlation of IL-4 in patients with HBV infection.Methods Sixty cases with chronic asymptomatic HBV carriers,60 cases with chronic hepatitis B,60 cases with liver cirrhosis,60 cases with hepato-cellular carcinoma and 50 healthy controls were collected for serum.ELISA was used for detection of cytokine IL-4 levels;The a-mount of HBV DNA was measured by fluorescence quantitative PCR;Liver function was tested by automatic biochemical analyzer. Results Compared with the healthy controls[(1.64±0.17)ng/mL],IL-4 levels of patients with CHB,LC and HCC were signifi-cantly increased[(4.18±0.48),(4.71±0.42),(3.62±0.31)ng/mL,P <0.05].LC group have the highest IL-4 levels,while ASC was the lowest.Compared with the ASC group,IL-4 levels of patients with CHB,LC and HCC were significantly increased(P <0.05).Compared with the HCC group,IL-4 levels of patients with LC were significantly increased(P <0.05).IL-4 level was posi-tively correlated with TBIL levels in LC patients(r=0.529,P <0.01),while the IL-4 level was positively correlated with ALT and TBIL level in HCC patients(r=0.263,0.323,P <0.05).Conclusion IL-4 may play an important role in chronic HBV infection, the levels of IL-4 can be used as an important indicator to assess the severity of chronic hepatitis B.
