Prognostic value of serumal copeptinin patientswith acute exacerbation of COPD complicated with respiratory failure

VernacularTitle:血清和肽素对慢性阻塞性肺急性加重伴呼吸衰竭预后的价值
Author: Hongjun AI ; Yuanjing CHEN ; Juan PENG
Keywords: chronicobstructive pulmonary disease; acute exacerbation; serumal copeptin; respiratory failure
From: International Journal of Laboratory Medicine 2017;38(2):229-230,232
CountryChina
Language:Chinese
Abstract: Objective To analyse the prognostic value of serumal copeptin in patients with acute exacerbation of COPD compli-cated withrespiratory failure.Methods The serumal copeptin were detected in 60 hospitalized AECOPD patients before and after the treatment and in 30 healthy controls.Results Comparing with control groups,the serumal levels was significantly elevated in the patient with AECOPD before thetreatment and declinied two months later(P <0.05).The level of serum copeptin wereincreasing with the increase in the severity of the disease in acertain extent;The serumalcopeptin were positively correlated with lung function and CAT (r=0.058 and 0.821,P =0.00)and were negativelycorrelated with 6MWD(r=-0.652,P =0.00).Conclusion Serum copeptin could as-sess the incidence of acute exacerbations ofchronic obstructive pulmonary disease and its therapeutic effect;Serum copeptin can reflect the se-verity of AECOPD patients in a certain extent,and has certain clinical value to evaluate the quality of life in patients.