Research progress of FBLN-5 in the role of tumorigensis
10.11958/20160855
- VernacularTitle:FBLN-5在肿瘤形成中作用的研究进展
- Author:
Dong AN
;
Junhong YANG
;
Xiaomeng SONG
- Keywords:
extracellular matrix;
FBLN-5;
integrin;
tumor angiogenesis;
epithelial-mesenchymal transition
- From:
Tianjin Medical Journal
2017;45(1):104-107,108
- CountryChina
- Language:Chinese
-
Abstract:
Fibulin protein family has widely existed in the extracellular matrix, and plays an important role in maintain the stable of basement membrane, elastic fibers and loose connective tissue. Fibulin-5 (FBLN-5) is one of the members of the Fibulin protein family, which is essential to the structure function and cell mediated action. The lack of FBLN-5 will cause many diseases such as internal organ deformity. Current research suggests that changes of expression level of FBLN-5 are associated with the occurrence of tumors such as lung cancer, and also can influence the tumor proliferation, invasion and prognosis, thus may become a new molecular marker for cancer diagnosis. Therefore, in this review, we summarize and update biological characteristics and functions of FBLN-5, and its role in the development of tumor formation mechanism.
